hrp0092p1-54 | Fat, Metabolism and Obesity | ESPE2019

Augmented Fibroblast Growth Factor 21 Serum Levels in Metabolic Disorders and Association With Endothelial Function in Childhood

Domouzoglou Eleni , Vlahos Antonios , Challa Anna , Papafaklis Michail , Tsatsoulis Agathocles , Michalis Lampros , Chaliasos Nikolaos , Naka Katerina

Introduction: Obesity and the metabolic syndrome (MetS) are linked to increased risk for endothelial dysfunction which is considered as the first step in the progression of cardiovascular disease. Fibroblast growth factor 21 (FGF21) is a protein with known effects on various metabolic pathways. In adults, the circulating blood levels of FGF21 have been associated with parameters of lipid/carbohydrate metabolism, and FGF21 is known to be increased in obesity. T...